Bluffton Seafood House

Restaurants in Bluffton, Bluffton, SC

Bluffton

Bluffton Seafood House on Mellichamp Drive is the sit-down restaurant arm of the Bluffton Oyster Company family — the same people who have been harvesting May River oysters for generations, now serving a full Lowcountry seafood menu in a proper dining room. Where the Oyster Company on Wharf Street is a working oyster house built around the harvest, the Seafood House is where you come for a complete meal: fried shrimp baskets, fish plates, deviled crab, she-crab soup, shrimp and grits, and oysters prepared multiple ways. The kitchen sources from the same local waters that supply the oyster house, which means the seafood is as fresh as it gets on this side of the bridge. The atmosphere is casual and unpretentious — no resort markup, no gimmicks, just honest Lowcountry cooking at fair prices in a welcoming neighborhood room. It draws a loyal local crowd of Bluffton residents who want a reliable weeknight seafood dinner, and visitors who have done their research and know to cross the bridge for the real thing. Call 843-757-0380 or visit blufftonoyster.com/our-restaurant for current hours and menu.

Address

27 Dr. Mellichamp Drive, Bluffton, SC 29910

Neighborhood

Bluffton

Phone

843-757-0380

Website

blufftonoyster.com/our-restaurant

Details last verified September 2026. Hours, pricing, and availability change — confirm directly with the business before visiting.